Fitoterapia 2011-09-01

Bisindole alkaloids and secoiridoids from Alstonia macrophylla Wall. ex G. Don.

Kanokwan Changwichit, Nantaka Khorana, Khanit Suwanborirux, Neti Waranuch, Nanteetip Limpeanchob, Wutichai Wisuitiprot, Nungruthai Suphrom, Kornkanok Ingkaninan

Index: Fitoterapia 82(6) , 798-804, (2011)

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Abstract

The ethanolic extract from stems of a Thai medicinal plant, Alstonia macrophylla Wall. ex G. Don (Apocynaceae) showed a significant inhibitory effect on acetylcholinesterase (AChE) determined by using Ellman assay. Four compounds i.e., a bisindole alkaloid, macralstonine (1), a new bisindole alkaloid, thungfaine (2), a secoiridoid glycoside, sweroside (3) and a new secoiridoid glycoside, naresuanoside (4) were isolated. Compound 4 showed moderate AChE and butyrylcholinesterase (BChE) inhibitory effects. Interestingly, compound 4 inhibited cell growth on human androgen-sensitive prostate cancer cell line (LNCaP) but no effect on viability of human foreskin fibroblast cells (HF).Copyright © 2011 Elsevier B.V. All rights reserved.