Tetrahedron

Fungal and bacterial regioselective hydroxylation of pyrimidine heterocycles

V Gotor, M Quirós, R Liz, J Frigola, R Fernández

Index: Gotor, Vicente; Quiros, Margarita; Ramon, Liz; Frigola, Jordi; Fernandez, Rosa Tetrahedron, 1997 , vol. 53, # 18 p. 6421 - 6432

Full Text: HTML

Citation Number: 21

Abstract

The bacterium Rhodococcus erythropolis is employed to hydroxylate the anxiolytic lesopitron, and this bacterium, together with Agrobacterium sp. and the fungus Beauveria bassiana, are used to extend the field of hydroxylation of heteroaromatic compounds to a series of unexplored pyrimidines. Of all the substrates investigated, only the carbamate 11a is regioselectively hydroxylated by B. bassiana at the C-5 position of the pyrimidine ring; in ...