Journal of Natural Products 2009-12-01

Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.

Hongjie Zhang, Katharina Rothwangl, Andrew D Mesecar, Ali Sabahi, Lijun Rong, Harry H S Fong

Index: J. Nat. Prod. 72(12) , 2158-62, (2009)

Full Text: HTML

Abstract

Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC(50) 2.31 muM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.