Biological & Pharmaceutical Bulletin 2007-10-01

N-trans-feruloyltyramine as a melanin biosynthesis inhibitor.

Mai Efdi, Kenji Ohguchi, Yukihiro Akao, Yoshinori Nozawa, Mamoru Koketsu, Hideharu Ishihara

Index: Biol. Pharm. Bull. 30(10) , 1972-4, (2007)

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Abstract

In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.