Planta Medica 2012-11-01

New phenolic compounds with anti-adipogenic activity from the aerial parts of Pulsatilla koreana.

Qing Liu, Jong Hoon Ahn, Seon Beom Kim, Bang Yeon Hwang, Mi Kyeong Lee

Index: Planta Med. 78(16) , 1783-6, (2012)

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Abstract

Three new phenolic compounds, pulsatillosides A (1), B (2), and C (3), were isolated from the aerial parts of Pulsatilla koreana, together with two known flavonoid glycosides, trans-tiliroside (4) and kaempferol-3-O-β-glycoside (5). The structures of the isolated compounds were determined on the basis of spectroscopic analysis including 1D, 2D NMR and HR-MS. Among the isolated compounds, compounds 1-3 significantly inhibited adipocyte differentiation as measured by fat accumulation in 3 T3-L1 cells using Oil Red O staining.Georg Thieme Verlag KG Stuttgart · New York.