Organic Letters 2013-09-06

Rh(III)-catalyzed tandem C-H allylation and oxidative cyclization of anilides: a new entry to indoles.

Ana Cajaraville, Susana López, Jesús A Varela, Carlos Saá

Index: Org. Lett. 15(17) , 4576-9, (2013)

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Abstract

Rh(III)-catalyzed tandem C-H allylation and oxidative cyclization of anilides with allyl carbonates in the presence of a slight excess of AgSbF6 salt and Cu(OAc)2 as oxidant affords easy, economical access to important bioactive 2-methylindoles. The new reaction supports a wide range of functional groups on the anilide substrate. A possible mechanism is proposed as a basis for its rational further development.