Bioorganic & Medicinal Chemistry Letters 2012-01-01

Synthesis and antihyperglycemic evaluation of new 2,4-thiazolidinediones having biodynamic aryl sulfonylurea moieties.

Dhanaji V Jawale, Umesh R Pratap, Neha Rahuja, Arvind K Srivastava, Ramrao A Mane

Index: Bioorg. Med. Chem. Lett. 22(1) , 436-9, (2012)

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Abstract

New 2,4-thiazolidinediones with aryl sulfonylurea moieties have been synthesized by condensing various substituted sulfonamides and 5-(isocyanatomethyl) thiazolidino-2,4-dione. The isocyanomethyl thiazolidinedione was obtained by using the Curtius rearrangement, starting from known 2,4-dioxo-5-thiazolidineacetic acid. The newly synthesized compounds have been evaluated for the antihyperglycemic activity in normal rats model and among these compounds showed significant antihyperglycemic activity in sucrose loaded rat model.Copyright © 2011 Elsevier Ltd. All rights reserved.