2,4-Thiazolidinedione

Modify Date: 2025-08-23 19:06:32

2,4-Thiazolidinedione Structure
2,4-Thiazolidinedione structure
 Common Name 2,4-Thiazolidinedione
CAS Number 2295-31-0 Molecular Weight 117.13
Density 1.5±0.1 g/cm3 Boiling Point 178-179 ºC (19 mmHg)
Molecular Formula C3H3NO2S Melting Point 123-126 ºC
MSDS Chinese USA Flash Point 138.7±19.3 °C

 Use of 2,4-Thiazolidinedione


2,4-Thiazolidinedione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

 Names

Name 1,3-thiazolidine-2,4-dione
Synonym More Synonyms

 2,4-Thiazolidinedione Biological Activity

Description 2,4-Thiazolidinedione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog
In Vitro PPARγ 激动剂。胰岛素增敏剂。

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 178-179 ºC (19 mmHg)
Melting Point 123-126 ºC
Molecular Formula C3H3NO2S
Molecular Weight 117.13
Flash Point 138.7±19.3 °C
Exact Mass 116.988449
PSA 71.47000
LogP -0.54
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.577

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ5775000
CHEMICAL NAME :
2,4-Thiazolidinedione
CAS REGISTRY NUMBER :
2295-31-0
BEILSTEIN REFERENCE NO. :
0110700
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C3-H3-N-O2-S
MOLECULAR WEIGHT :
117.13
WISWESSER LINE NOTATION :
T5SVMV EHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
335 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 9,274,1954

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS XJ5775000
HS Code 2942000000

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles53

More Articles
Cytotoxicity of thiazolidinedione-, oxazolidinedione- and pyrrolidinedione-ring containing compounds in HepG2 cells.

Toxicol. In Vitro 29 , 1887-96, (2015)

Liver damage occurred in some patients who took troglitazone (TGZ) for type II diabetes. The 2,4-thiazolidinedione (TZD) ring in TGZ's structure has been implicated in its hepatotoxicity. To further e...

Differential cardiovascular outcomes after dipeptidyl peptidase-4 inhibitor, sulfonylurea, and pioglitazone therapy, all in combination with metformin, for type 2 diabetes: a population-based cohort study.

PLoS ONE 10 , e0124287, (2015)

Data on the comparative effectiveness of oral antidiabetics on cardiovascular outcomes in a clinical practice setting are limited. This study sought to determine whether a differential risk of cardiov...

Effects of Various 5,7-Dihydroxyflavone Analogs on Adipogenesis in 3T3-L1 Cells.

Biol. Pharm. Bull. 38 , 1794-800, (2015)

We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among the compounds, luteolin, diosmetin, and chrysoeriol partly inhibited adipogenesis by blocking the a...

 Synonyms

EINECS 218-941-2
2(5H)-Thiazolone, 4-hydroxy-
2,4-Thiazolidindione
usafek-5496
2,4-dioxothiazolidine
Thiazolidinedione
2,4-Thiazolidinedione
1,3-Thiazolidine-2,4-dione
2-thiazolidin-4-one
2,4-thiazolidinone
thiazolidine-2,4-dione
2,4-Thiazolinedione
4-Hydroxy-1,3-thiazol-2(5H)-one
MFCD00005478
TZD
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Chemsrc provides 2,4-Thiazolidinedione(CAS#:2295-31-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 2,4-Thiazolidinedione are included as well.>> amp version: 2,4-Thiazolidinedione

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