Journal of Organic Chemistry 2012-10-05

Palladium-catalyzed annulation of arynes by o-halobenzamides: synthesis of phenanthridinones.

Chun Lu, Anton V Dubrovskiy, Richard C Larock

Index: J. Org. Chem. 77(19) , 8648-56, (2012)

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Abstract

The palladium-catalyzed annulation of arynes by substituted o-halobenzamides produces N-substituted phenanthridinones in good yields. This methodology provides this important heterocyclic ring system in a single step by simultaneous C-C and C-N bond formation, under relatively mild reaction conditions, and tolerates a variety of functional groups.