Tetrahedron Letters

Copper-catalyzed cyanation of aryl iodide with the combined cyanide source of urea and DMSO

K Zheng, B Liu, S Chen, F Chen

Index: Zheng, Kui; Liu, Bin; Chen, Shuyou; Chen, Fan Tetrahedron Letters, 2013 , vol. 54, # 38 p. 5250 - 5252

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Citation Number: 4

Abstract

Abstract A simple copper-catalyzed cyanation of aryl iodide with the combination of urea and dimethyl sulfoxide as a cyanide source is achieved, providing nitriles in moderate to good yields. This new approach represents an exceedingly practical and safe method for the synthesis of aryl nitriles.

~45%

~62%

~53%

~56%

~89%

~11%

~93%

~73%

~41%

~42%

~92%

~82%

~78%

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