Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 2012-01-01

[Effects of penetration enhancers on curcumin transdermal drug delivery].

Zhen-Shen Gao, Lan Wang, Mei Zhang

Index: Zhong Yao Cai 35(1) , 141-4, (2012)

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Abstract

To study the effects of penetration enhancers and their combinations on the curcumine transdermal drug delivery (CUR-TDDS).The penetration rate of curcumin through rat skin in vitro was measured using Valia-Chien diffusion cells, and orthogonal design method was set up for experimental design.The optimum penetration enhancers were: 3% hydroxypropyl beta cyclodextrins (HP-beta-CD), 9% borneol and 3% peppermint oil.The HP-beta-CD has the most potent enhancing effect.