Bioorganic & Medicinal Chemistry Letters 2003-09-01

Synthesis and biological evaluation of a novel phenyl substituted sydnone series as potential antitumor agents.

Christopher S Dunkley, Charles J Thoman

Index: Bioorg. Med. Chem. Lett. 13 , 2899-2901, (2003)

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Abstract

A series of compounds containing an N-(4'-substituted-3'-nitrophenyl)sydnone moiety with potential antitumor activity was prepared based on active analogues. The rationale behind the design of these compounds is presented along with the 4-step synthetic route to the derivatives in the 4'-position of the phenyl sydnone framework. Out of the six novel compounds, the 4'-fluoro derivative has an improved activity against all three cell lines as compared to the earlier leads.