European Journal of Pharmacology 2012-09-05

Involvement of monoamine oxidase B on models of postoperative and neuropathic pain in mice.

Jardel Gomes Villarinho, Sara Marchesan Oliveira, Cássia Regina Silva, Thaíssa Nunes Cabreira, Juliano Ferreira

Index: Eur. J. Pharmacol. 690(1-3) , 107-14, (2012)

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Abstract

In this study we assessed the involvement of monoamine oxidase B (MAO-B), a key enzyme implicated in monoamine metabolism, on postoperative (plantar incision) and neuropathic (partial sciatic nerve ligation) pain models in mice. Paw incision submitted mice showed a significant decrease in mechanical threshold compared with the sham-operated mice, characterizing the development of mechanical allodynia. The selective and irreversible MAO-B inhibitor selegiline, at a dose sufficient to selectively inhibit MAO-B activity (10 mg/kg), showed an anti-allodynic effect from 0.5 to 6 h after incision. Likewise, partial sciatic nerve ligation submitted mice also developed mechanical allodynia, which was reversed by selegiline (10 mg/kg) from 2 to 6 h after treatment. In addition, a significant increase on striatal MAO-B activity was observed in neuropathic mice compared with the sham-operated animals, which was reversed by selegiline treatment. Taken together, our results showed that MAO-B seems to exert a critical role in the development of postoperative and neuropathic pain.Copyright © 2012 Elsevier B.V. All rights reserved.