selegiline
selegiline structure
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Common Name | selegiline | ||
|---|---|---|---|---|
| CAS Number | 14611-51-9 | Molecular Weight | 187.28100 | |
| Density | 0.954g/cm3 | Boiling Point | 272.5ºC at 760 mmHg | |
| Molecular Formula | C13H17N | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 108.4ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Design and application of an in vivo reporter assay for phenylalanine ammonia-lyase.
Appl. Microbiol. Biotechnol. 97(17) , 7877-85, (2013) Phenylalanine ammonia-lyase (PAL) is an important enzyme that links primary metabolism to secondary metabolism. Its efficiency is often a critical factor that affects the overall flux of a related metabolic pathway, the titer of the final products, and the ef... |
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A (p)ppGpp-null mutant of Haemophilus ducreyi is partially attenuated in humans due to multiple conflicting phenotypes.
Infect. Immun. 82(8) , 3492-502, (2014) (p)ppGpp responds to nutrient limitation through a global change in gene regulation patterns to increase survival. The stringent response has been implicated in the virulence of several pathogenic bacterial species. Haemophilus ducreyi, the causative agent of... |
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Mutational analysis of the (p)ppGpp synthetase activity of the Rel enzyme of Mycobacterium tuberculosis.
Arch. Microbiol. 196(8) , 575-88, (2014) Rel(Mtb), a GTP pyrophosphokinase encoded by the Mycobacterium tuberculosis (Mtb) genome, catalyzes synthesis of (p)ppGpp from ATP and GDP(GTP) and its hydrolysis to GDP(GTP) and pyrophosphate to mediate stringent response, which helps bacteria to survive dur... |
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Evidence for a catalytically and kinetically competent enzyme-substrate cross-linked intermediate in catalysis by lipoyl synthase.
Biochemistry 53(28) , 4557-72, (2014) Lipoyl synthase (LS) catalyzes the final step in lipoyl cofactor biosynthesis: the insertion of two sulfur atoms at C6 and C8 of an (N(6)-octanoyl)-lysyl residue on a lipoyl carrier protein (LCP). LS is a member of the radical SAM superfamily, enzymes that us... |
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Ketoacyl synthase domain is a major determinant for fatty acyl chain length in Saccharomyces cerevisiae.
Arch. Microbiol. 195(12) , 843-52, (2013) Yeast fatty acid synthase (Fas) comprises two subunits, α6 and β6, encoded by FAS2 and FAS1, respectively. To determine features of yeast Fas that control fatty acyl chain length, chimeric genes were constructed by combining FAS sequences from Saccharomyces c... |
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Microbial production of short-chain alkanes.
Nature 502(7472) , 571-4, (2013) Increasing concerns about limited fossil fuels and global environmental problems have focused attention on the need to develop sustainable biofuels from renewable resources. Although microbial production of diesel has been reported, production of another much... |
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A ferrofluid-based homogeneous assay for highly sensitive and selective detection of single-nucleotide polymorphisms.
Chem. Commun. (Camb.) 49(73) , 8114-6, (2013) A simple and low-cost colorimetric assay utilizing ferrofluidic nanoparticulate probes (FNPs) and a ligase for single-nucleotide polymorphism genotyping is described. Excellent sensitivity and selectivity were accomplished through the engagement of the FNPs a... |
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Fbw7 dimerization determines the specificity and robustness of substrate degradation.
Genes Dev. 27(23) , 2531-6, (2013) The Fbw7 tumor suppressor targets a broad network of proteins for ubiquitylation. Here we show critical functions for Fbw7 dimerization in regulating the specificity and robustness of degradation. Dimerization enables Fbw7 to target substrates through concert... |
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[Roles of hMMS2 gene in reversing the oxaliplatin tolerance of human colon carcinoma cells].
Yi Chuan 36(4) , 346-53, (2014) In this study, the roles of hMMS2 (human methyl methanesulfonate sensitive mutant 2) gene encoding the human ubiquitin-conjugating enzyme E2 variant 2 in the drug resistance in human colon carcinoma were investigated by using a well-differentiated human color... |
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Trapping the dynamic acyl carrier protein in fatty acid biosynthesis.
Nature 505(7483) , 427-31, (2014) Acyl carrier protein (ACP) transports the growing fatty acid chain between enzymatic domains of fatty acid synthase (FAS) during biosynthesis. Because FAS enzymes operate on ACP-bound acyl groups, ACP must stabilize and transport the growing lipid chain. ACPs... |