Fertility and Sterility 2011-02-01

Inhibition of CD44 N- and O-linked glycosylation decreases endometrial cell lines attachment to peritoneal mesothelial cells.

Allison K Rodgers, Anitha Nair, Peter A Binkley, Rajeshwar Tekmal, Robert S Schenken

Index: Fertil. Steril. 95(2) , 823-5, (2011)

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Abstract

The attachment of endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) with and without inhibition of N- and O-linked glycosylation, the viability of EECs and ESCs, and the expression of CD44 surface density were evaluated. Inhibition of CD44 N- and O-linked glycosylation by using tunicamycin and/or B-GalNAc statistically significantly inhibited endometrial cell attachment to peritoneal mesothelial cells, suggesting a role in establishment of early endometriotic lesions.Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.