Tetrahedron Letters

Synthesis of indoles through Rh (III)-catalyzed C–H cross-coupling with allyl carbonates

TJ Gong, WM Cheng, W Su, B Xiao, Y Fu

Index: Gong, Tian-Jun; Cheng, Wan-Min; Su, Wei; Xiao, Bin; Fu, Yao Tetrahedron Letters, 2014 , vol. 55, # 11 p. 1859 - 1862

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Citation Number: 16

Abstract

Abstract A practical Rh-catalyzed reaction was developed to achieve 2-alkyl-substituted indole synthesis. The reaction can tolerate a variety of synthetically important functional groups. The indole products can also be transformed into other important skeletons. Two bioactive compounds, that is indomethacin and pravadoline were prepared using the new method.