Chemical & Pharmaceutical Bulletin 2010-11-01

Synthesis and antiviral activities of synthetic glutarimide derivatives.

Xing-yue Ji, Zhao-jin Zhong, Si-tu Xue, Shuai Meng, Wei-ying He, Rong-mei Gao, Yu-huan Li, Zhuo-rong Li

Index: Chem. Pharm. Bull. 58(11) , 1436-41, (2010)

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Abstract

A series of novel glutarimide compounds were synthesized and their antiviral activities were evaluated. The compounds displaying the strongest antiviral activities included 5, 6f, 7e and 9 against coxsackievirus B3 (Cox B3), 10 and 6f against influenza virus A (influenza A) and 7a against herpes simplex virus 2 (HSV-2). However, most of the synthetic glutarimides showed comparatively much weaker activity against influenza A, Cox B3 and HSV-2 than the natural glutarimide compounds tested. Based on the results, it seemed likely that a conjugated system at the β-substituted moiety provides stronger antiviral activity.