Glutarimide

Modify Date: 2024-01-04 06:11:49

Glutarimide Structure
Glutarimide structure
Common Name Glutarimide
CAS Number 1121-89-7 Molecular Weight 113.115
Density 1.2±0.1 g/cm3 Boiling Point 288.0±9.0 °C at 760 mmHg
Molecular Formula C5H7NO2 Melting Point 155-157 °C(lit.)
MSDS Chinese USA Flash Point 152.3±18.9 °C

 Names

Name piperidine-2,6-dione
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 288.0±9.0 °C at 760 mmHg
Melting Point 155-157 °C(lit.)
Molecular Formula C5H7NO2
Molecular Weight 113.115
Flash Point 152.3±18.9 °C
Exact Mass 113.047676
PSA 46.17000
LogP -0.04
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.471

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA4000000
CHEMICAL NAME :
Glutarimide
CAS REGISTRY NUMBER :
1121-89-7
BEILSTEIN REFERENCE NO. :
0110052
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H7-N-O2
MOLECULAR WEIGHT :
113.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 173,115,1968

 Safety Information

Hazard Codes Xi:Irritant;
Risk Phrases R36
Safety Phrases S37/39-S26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS MA4000000
HS Code 2925190090

 Synthetic Route

 Customs

HS Code 2925190090
Summary 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles29

More Articles
Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.

Biochemistry 53(49) , 7854-65, (2014)

Lactimidomycin (LTM, 1) and iso-migrastatin (iso-MGS, 2) belong to the glutarimide-containing polyketide family of natural products. We previously cloned and characterized the mgs biosynthetic gene cl...

Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds.

J. Am. Chem. Soc. 127(34) , 11930-1, (2005)

Iso-Migrastatin (10) has been shown to be the main natural product of Streptomyces platensis, which undergoes a facile, H2O-mediated rearrangement into dorrigocin A (2), 13-epi-dorrigocin A (11), dorr...

Enantiomerization mechanism of thalidomide and the role of water and hydroxide ions.

Chemistry 18(45) , 14305-13, (2012)

The significance of the molecular chirality of drugs has been widely recognized due to the thalidomide tragedy. Most of the new drugs reaching the market today are single enantiomers, rather than race...

 Synonyms

2,6-Piperidinedione
GlutariMide 25GR
Glutarimide
piperidin-1-yl-2,6-dione
EINECS 214-340-4
2,6-Diketopiperidine2,6-Piperidinedione
Piperidine-2,6-dione
MFCD00006670
2,6-dioxopiperidine
2,6-Piperidinedione (9CI)
L-glutarimide
2,6-DIKETOPIPERIDINE
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