Biocatalytic approach to enantiomerically pure β-amino acids

…, IP Shishkina, SV Galushko, AE Sorochinsky…

Index: Soloshonok; Fokina; Rybakova; Shishkina; Galushko; Sorochinsky; Kukhar; Savchenko; Svedas Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1601 - 1610

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Citation Number: 94

Abstract

β-Aryl-β-amino acids were prepared in good chemical yield and high enantiomeric purity (> 95% ee) via penicillin acylase-catalyzed hydrolysis of the corresponding N-phenylacetyl derivatives. The (R)-enantiomers were the fast-reacting isomers in all cases studied. The ...

~70%

~59%

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