Cardiac glycosides. 7. Sugar stereochemistry and cardiac glycoside activity

…, AHL From, K Ahmed, DS Fullerton

Index: Rathore, Hargovind; From, Arthur H. L.; Ahmed, Khalil; Fullerton, Dwight S. Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1945 - 1952

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Citation Number: 54

Abstract

Digitoxigenin (YL-, pL-, CY-D-, and PD-glucosides; aL-, pL-, a+, and PD-mannosides; and CY-L-and PL-rhamnosides were stereoselectively synthesized from the corresponding sugar tetrabenzyl trichloroacetimidates. The Na+, K+-ATPme receptor inhibitory activities ...