Neurobiology of Aging 1993-01-01

Chronic methanesulfonyl fluoride enhances one-trial per day reward learning in aged rats.

D H Malin, R E Plotner, S J Radulescu, R N Ferebee, J R Lake, P G Negrete, P J Schaefer, M K Crothers, D E Moss

Index: Neurobiol. Aging 14(4) , 393-5, (1993)

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Abstract

Aged (24-month-old) rats were treated chronically with methanesulfonyl fluoride (MSF), an acetylcholinesterase (AChE) inhibitor with selectivity for central nervous system AChE, or with injection vehicle alone. Twelve 0.22 mg/kg IP injections were given over 4 weeks. MSF rats showed significantly greater speed and accuracy on a 1 trial/day discriminative reward learning task. The chronic MSF treatment resulted in a 56% decrease in brain AChE activity but no discernable locomotor side effects and no liver damage as indicated by aspartate transferase activity.