Nitric Oxide 2012-05-15

Analysis of responses to glyceryl trinitrate and sodium nitrite in the intact chest rat

Bobby D. Nossaman, Edward A. Pankey, Adeleke R. Badejo, David B. Casey, Satvika Uppu, Subramanyam N. Murthy, Philip J. Kadowitz

Index: Nitric Oxide 26(4) , 223-8, (2012)

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Abstract

Highlights ► Nitroglycerin/glyceryl trinitrate (GTN) has been used for over 140years. ► Mechanism of action remains unknown. ► GTN metabolizes to 1,2-GDN and nitrite anion. ► Nitrite anion derived from GTN does not produce nitric oxide.