Tetrahedron

A highly efficient palladium-catalyzed desulfitative arylation of azoles with sodium arylsulfinates

M Wang, D Li, W Zhou, L Wang

Index: Wang, Min; Li, Dengke; Zhou, Wei; Wang, Lei Tetrahedron, 2012 , vol. 68, # 7 p. 1926 - 1930

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Citation Number: 69

Abstract

A highly efficient palladium-catalyzed direct desulfitative arylation of azoles at C2-position has been developed using sodium arylsulfinates as aryl sources. Azoles including benzoxazoles, benzothiazoles, oxazoles, thiazoles, and 1, 3, 4-oxadiazoles reacted with sodium arylsulfinates smoothly to generate the corresponding products in good to excellent yields, and various substitution patterns were tolerated toward the reaction.

~85%

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~91%

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~74%

~85%

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~49%

~66%

~72%

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