Heterocycles

An efficient arylation of benzoazoles with aryl bromides by a practical palladium-copper cocatalytic system

XM Yan, XR Mao, ZZ Huang

Index: Yan, Xue-Ming; Mao, Xue-Rong; Huang, Zhi-Zhen Heterocycles, 2011 , vol. 83, # 6 p. 1371 - 1376

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Citation Number: 17

Abstract

Abstract–A practical, efficient Pd (OAc) 2/Cu (II)/PPh3 cocatalytic system has been developed. With only 1 mol% Pd (OAc) 2, 20 mol% copper (II) salt, and 0.5 equiv of inexpensive PPh3 as ligand, the direct arylation of benzoazoles with aryl bromides could be performed smoothly in mild condition, affording the desired arylated benzoazoles in good yields (75-93%).

~84%

~75%

~91%

~82%

~78%

~86%

~85%

~80%

~80%

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