Journal of Chromatographic Science 2010-07-01

LC for analysis of two sustained-release mixtures containing cough cold suppressant drugs.

Alaa El-Gindy, Shehab Sallam, Randa A Abdel-Salam

Index: J. Chromatogr. Sci. 48(6) , 507-12, (2010)

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Abstract

A liquid chromatographic method was applied for the analysis of two sustained-release mixtures containing dextromethorphane hydrobromide, carbinoxamine maleate with either phenylephrine hydrochloride in pharmaceutical capsules (Mix 1) or phenyl-propanolamine, methylparaben, and propylparaben, which bonds as a drug base to ion exchange resin in pharmaceutical syrup (Mix 2). The method was used for their simultaneous determination using a CN column with a mobile phase consisting of acetonitrile-12 mM ammonium acetate in the ratio of 60:40 (v/v, pH 6.0) for Mix 1 and 45:55 (v/v, pH 6.0) for Mix 2.