Propyl paraben

Modify Date: 2024-01-02 01:48:22

Propyl paraben Structure
Propyl paraben structure
Common Name Propyl paraben
CAS Number 94-13-3 Molecular Weight 180.201
Density 1.1±0.1 g/cm3 Boiling Point 294.3±13.0 °C at 760 mmHg
Molecular Formula C10H12O3 Melting Point 95-98 °C(lit.)
MSDS Chinese USA Flash Point 124.6±12.6 °C

 Use of Propyl paraben


Propylparaben is an antimicrobial agent, preservative, flavouring agent.

 Names

Name propylparaben
Synonym More Synonyms

 Propyl paraben Biological Activity

Description Propylparaben is an antimicrobial agent, preservative, flavouring agent.
Related Catalog
Target

Human Endogenous Metabolite

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 294.3±13.0 °C at 760 mmHg
Melting Point 95-98 °C(lit.)
Molecular Formula C10H12O3
Molecular Weight 180.201
Flash Point 124.6±12.6 °C
Exact Mass 180.078644
PSA 46.53000
LogP 2.93
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.532
Stability Stable. Incompatible with strong oxidizing agents, strong bases.
Water Solubility <0.1 g/100 mL at 12 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DH2800000
CHEMICAL NAME :
Benzoic acid, p-hydroxy-, propyl ester
CAS REGISTRY NUMBER :
94-13-3
BEILSTEIN REFERENCE NO. :
1103245
LAST UPDATED :
199701
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C10-H12-O3
MOLECULAR WEIGHT :
180.22
WISWESSER LINE NOTATION :
QR DVO3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6332 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946- Volume(issue)/page/year: 28,463,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,135,1960
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 146,208,1929 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,575,1954 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80496 No. of Facilities: 2827 (estimated) No. of Industries: 21 No. of Occupations: 36 No. of Employees: 48242 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80496 No. of Facilities: 13566 (estimated) No. of Industries: 86 No. of Occupations: 117 No. of Employees: 526606 (estimated) No. of Female Employees: 355310 (estimated)

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS DH2800000
HS Code 2918290000

 Synthetic Route

~78%

Propyl paraben Structure

Propyl paraben

CAS#:94-13-3

Literature: Owen, Caroline; James, Karen; Sampson, Luther; Ahmed, Sabbir Journal of Pharmacy and Pharmacology, 2003 , vol. 55, # 1 p. 85 - 93

~95%

Propyl paraben Structure

Propyl paraben

CAS#:94-13-3

Literature: Chakraborti, Asit K.; Nayak, Mrinal K.; Sharma, Lalima Journal of Organic Chemistry, 2002 , vol. 67, # 6 p. 1776 - 1780

~%

Propyl paraben Structure

Propyl paraben

CAS#:94-13-3

Detail
Literature: Chemical Papers, , vol. 64, # 3 p. 405 - 408

 Customs

HS Code 2918290000
Summary HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

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Development and application of a validated stability-indicating high-performance liquid chromatographic method using photodiode array detection for simultaneous determination of granisetron, methylparaben, propylparaben, sodium benzoate, and their main degradation products in oral pharmaceutical preparations.

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 Synonyms

Propyl parahydroxybenzoate
Propyl-4-​hydroxybe​nzoate
Mekkings P
4-hydroxybenzoic acid propyl ester
nipaginp
PROPYL PARASEPT
Nipasol M
Benzoic acid, p-hydroxy-, propyl ester
N-Propyl-p-hydroxybenzoate
Propyl chemosept
nipasolp
n-Propyl p-hydroxybenzoate
n-propyl 4-hydroxybenzoate
n-Propylparaben
Paseptol
Nipazol
4-Hydroxybenzoic acid, n-propyl ester
EINECS 202-307-7
propyl paraben
Solbrol P
p-Hydroxybenzoic acid n-propyl ester
Propagin
4-Hydroxybenzoic acid n-propyl ester
propyl p-hydroxybenzoate
Benzoic acid, 4-hydroxy-, propyl ester
p-Hydroxybenzoic acid, propyl ester
p-hydroxybenzoic acid propyl ester
Nipasol
Parabens
Propylparaben
n-Propyl-4-hydroxy-benzoate
solbrolp
Propyl 4-hydroxybenzoate
NipasolM
betacidep
MFCD00002354
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