From adenosine to 3'-deoxyadenosine: development and scale up

S Aman, DJ Anderson, TJ Connolly…

Index: Schirmeister-Tichy, Helga; Iacono, Kathryn T.; Muto, Nicholas F.; Homan, Joseph W.; Suhadolnik, Robert J.; Pfleiderer, Wolfgang Helvetica Chimica Acta, 1999 , vol. 82, # 4 p. 597 - 613

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Citation Number: 28

Abstract

... It was also discovered during the stage one development that the reaction worked better in a 50/50 (w/w) mixture of acetonitrile/ethyl acetate, and ... dd, J = 12.5, 6.0 Hz, 1H), 3.81 (dd, J = 12.5, 6.0 Hz, 1H), 4.40 (q, J = 6.0 Hz 1H), 4.59 (dd, J = 6.0, 3.5 Hz, 1H), 4.78 (t, J = 3.5 Hz ...

~50%

Synthesis of 3′-azido-and 3′-amino-3′-deoxyadenosine in both...

[Botta, Oliver; Moyroud, Elisabeth; Lobato, Cinta; Strazewski, Peter Tetrahedron, 1998 , vol. 54, # 44 p. 13529 - 13546]

An efficient synthesis of 3′??amino??3′??deoxyguanosine from...

[Zhang, Lei; Cui, Zhiyong; Zhang, Biliang Helvetica Chimica Acta, 2003 , vol. 86, # 3 p. 703 - 710]

Syntheses of Puromycin from Adenosine and 7-Deazapuromycin f...

[Robins, Morris J.; Miles, Robert W.; Samano, Mirna C.; Kaspar, Roger L. Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8204 - 8210]