Farmakologiia i toksikologiia 1991-01-01

[The action of amtizol and gutimin on the respiratory metabolism of the neuron].

S S Sergeeva, I N Ianvareva, O Iu Uriupov, A B Tomchin

Index: Farmakol. Toksikol. 54(3) , 22-4, (1991)

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Abstract

The effects of antihypoxants gutimine and amtisole on oxygen consumption by the intact nerve cell of the invertebrate and the activity of NADN-DH and SDH-dependent ways of oxidation in the cell were studied. Under normoxia gutimine inhibited the nerve cell respiration and decreased the activity of NADN-DN and SDH-dependent ways of oxidation by 15% and 5% respectively. Amtisole activated the neuron respiration increasing the activity of NADN-DH-dependent way of oxidation. Both antihypoxants, despite the fact that they refer to the same class of compounds, have different mechanisms of action on the neuron metabolism. Gutimine appears to be a pharmacological agent, protector, amtisole as an initiator of the active adaptative reorganization of the intracellular metabolism.