Potential radiosensitizing agents. 2. Synthesis and biological activity of derivatives of dinitroimidazole with oxiranes

RK Sehgal, MW Webb, KC Agrawal

Index: Sehgal, Raj K.; Webb, Matthew W.; Agrawal, Krishna C. Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 601 - 604

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Citation Number: 17

Abstract

A series of l-substituted 2, 4-dinitroimidazole analogues have been synthesized and tested for their radiosensitizing ability for selectively sensitizing hypoxic mammalian cells to the lethal effect of radiation. The reaction of 2, 4-(5)-dinitroimidazole (1) with a variety of oxiranes upon heating in absolute ethanol yielded the expected l-substituted 2, 4- dinitroimidazoles (2) and also resulted in the formation of a novel class of isomeric ...