Toxicology Letters 2013-06-07

Zeranol upregulates corticotropin releasing hormone expression in the placental cell line JEG-3

Yanfei Wang, Wenjuan Tan, Lai K. Leung

Index: Toxicol. Lett. 219(3) , 218-22, (2013)

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Abstract

• Zeranol induced CRH mRNA expression in JEG-3 cells at sub-nM range. • ERK and PKCδ in the placental cells were activated. • CRE-binding activity in the CRH gene promoter was increased.