European Journal of Drug Metabolism and Pharmacokinetics 1997-01-01

Comutagenesis--V: rapid conversion of 2-hydroxyl-amino-3-methylpyridineto 2-amino-3-methylpyridine by a hepatic S9 preparation.

J W Gorrod, T G Altuntas

Index: Eur. J. Drug Metab. Pharmacokinet. 22(4) , 341-4, (1997)

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Abstract

The in vitro metabolism of 2-hydroxylamino-3-methylpyridine has been investigated using arochlor 1254 pretreated rat S9 mixtures. 2-Hydroxylamino-3-methylpyridine is rapidly converted to the parent amine 2-amino-3-methylpyridine. No further oxidation products of 2-hydroxylamino-3-methylpyridine (i.e. nitroso or nitro) were detected under the HPLC conditions used. This observation may explain our previous findings on the in vitro metabolism of 2-amino-3-methylpyridine where no hydroxylamino metabolite was detected.