3-Methylpyridin-2-amine

Modify Date: 2024-01-02 17:21:33

3-Methylpyridin-2-amine Structure
3-Methylpyridin-2-amine structure
Common Name 3-Methylpyridin-2-amine
CAS Number 1603-40-3 Molecular Weight 108.141
Density 1.1±0.1 g/cm3 Boiling Point 220.9±20.0 °C at 760 mmHg
Molecular Formula C6H8N2 Melting Point 29-31 °C(lit.)
MSDS Chinese USA Flash Point 111.7±0.0 °C
Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger

 Names

Name 2-Amino-3-picoline
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 220.9±20.0 °C at 760 mmHg
Melting Point 29-31 °C(lit.)
Molecular Formula C6H8N2
Molecular Weight 108.141
Flash Point 111.7±0.0 °C
Exact Mass 108.068748
PSA 38.91000
LogP 1.08
Vapour Pressure 0.1±0.4 mmHg at 25°C
Index of Refraction 1.574
Water Solubility SOLUBLE

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US1850000
CHEMICAL NAME :
Pyridine, 2-amino-3-methyl-
CAS REGISTRY NUMBER :
1603-40-3
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C6-H8-N2
MOLECULAR WEIGHT :
108.16
WISWESSER LINE NOTATION :
T6NJ BZ C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
650 ppm/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
36 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 36,491,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01585
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

 Safety Information

Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H301-H311-H331-H373
Precautionary Statements P261-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic;
Risk Phrases R25;R36/37/38
Safety Phrases S36/37/39-S45-S37/39-S28A-S26
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS US1850000
Packaging Group II
Hazard Class 6.1
HS Code 29333999

 Synthetic Route

~98%

3-Methylpyridin-2-amine Structure

3-Methylpyridin...

CAS#:1603-40-3

Literature: Elmkaddem, Mohammed K.; Fischmeister, Cedric; Thomas, Christophe M.; Renaud, Jean-Luc Chemical Communications, 2010 , vol. 46, # 6 p. 925 - 927

~%

3-Methylpyridin-2-amine Structure

3-Methylpyridin...

CAS#:1603-40-3

Literature: Organic Letters, , vol. 15, # 14 p. 3734 - 3737

~%

3-Methylpyridin-2-amine Structure

3-Methylpyridin...

CAS#:1603-40-3

Literature: Journal of Organic Chemistry, , vol. 72, # 12 p. 4554 - 4557

~%

3-Methylpyridin-2-amine Structure

3-Methylpyridin...

CAS#:1603-40-3

Literature: Chemistry - A European Journal, , vol. 16, # 6 p. 1983 - 1991

~%

3-Methylpyridin-2-amine Structure

3-Methylpyridin...

CAS#:1603-40-3

Literature: Chemische Berichte, , vol. 57, p. 1804 Chemische Berichte, , vol. 58, p. 1733

~%

3-Methylpyridin-2-amine Structure

3-Methylpyridin...

CAS#:1603-40-3

Literature: Bioorganic and medicinal chemistry letters, , vol. 10, # 17 p. 1975 - 1978

~%

3-Methylpyridin-2-amine Structure

3-Methylpyridin...

CAS#:1603-40-3

Literature: US2456379 , ;

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles5

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Synthesis and characterisation of two novel proton transfer compounds and their inhibition studies on carbonic anhydrase isoenzymes.

J. Enzyme Inhib. Med. Chem. 26(1) , 104-14, (2011)

Two novel proton transfer compounds were prepared between 2,4-dichloro-5-sulphamoylbenzoic acid (lasamide) (Hsba) and ethylenediamine (en), namely ethane-1,2-diaminium 2,4-dichloro-5-sulphamoylbenzoat...

Comutagenesis-III. In vitro metabolism of 2-amino-3-methylpyridine: the effect of various potential inhibitors, activators and inducers.

Xenobiotica 27(11) , 1103-11, (1997)

1. The effects of various potential inhibitors, activators and inducers on the metabolism of the comutagen 2-amino-3-methylpyridine (2A3MP) by rabbit hepatic microsomes and S9 supernatants have been s...

Comutagenesis-I: the in vitro metabolism of 2-amino-3-methylpyridine.

Anticancer Res. 17(5A) , 3485-91, (1997)

The metabolism of the comutagen 2-amino-3-methylpyridine has been studied in vitro using rat and rabbit hepatic preparations. 2-Amino-3-methylpyridine-N-oxide, 2-amino-3-hydroxymethylpyridine and 2-am...

 Synonyms

MFCD00006320
3-methylpyridin-2-amine
2-Pyridinamine, 3-methyl-
2-Amino-3-picoline
3-Methyl-2-pyridinamine
3-Methylpyridin-2-amin
EINECS 216-501-4
2-Amino-3-methylpyridine
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