Biochemical Journal 1980-03-01

Novel inhibitors of poly(ADP-ribose) synthetase.

M R Purnell, W J Whish

Index: Biochem. J. 185 , 775-777, (1980)

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Abstract

In a search for new inhibitors of the nuclear enzyme poly(ADP-ribose) synthetase, it was found that various benzamides substituted in the 3-position were the most inhibitory compounds found to date. Two of the benzamides, 3-aminobenzamide and 3-methoxybenzamide, were found to be competitive inhibitors, with Ki values or less than 2 microM.