3-Aminobenzamide

Modify Date: 2024-01-02 18:51:16

3-Aminobenzamide Structure
3-Aminobenzamide structure
 Common Name 3-Aminobenzamide
CAS Number 3544-24-9 Molecular Weight 136.151
Density 1.2±0.1 g/cm3 Boiling Point 329.6±25.0 °C at 760 mmHg
Molecular Formula C7H8N2O Melting Point 115-116 °C(lit.)
MSDS Chinese USA Flash Point 153.2±23.2 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of 3-Aminobenzamide


3-Aminobenzamide is a potent inhibitor of PARP with IC50 of appr 50 nM in CHO cells, and acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.

 Names

Name 3-aminobenzamide
Synonym More Synonyms

 3-Aminobenzamide Biological Activity

Description 3-Aminobenzamide is a potent inhibitor of PARP with IC50 of appr 50 nM in CHO cells, and acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.
Related Catalog
Target

PARP:50 nM (IC50)
In Vitro 3-Aminobenzamide (>1 μM) causes more than 95% inhibition of PARP activity without significant cellular toxicity. INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions[1]. 3-Aminobenzamide significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM H2O2[2].
In Vivo In a db/db (Leprdb/db) mouse model, 3-Aminobenzamide ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion[3]. 3-Aminobenzamide (1.6 mg/kg via intracerebral injection) prevents NAD+ depletion and improves water maze performance after controlled cortical impact (CCI) in mice[4].
Kinase Assay PARP activity is measured with a PARP Activity Assay Kit. This method measures relative PARP activity by determining the level of incorporation of 3H-NAD into trichloroacetic acid (TCA) precipitable material in the presence of sheared genomic DNA, which activates PARP. The reaction mixture is added directly to washed cultures in 12-well culture plates and the reaction is allowed to proceed for 60 minutes at 37°C before the cells are removed mechanically, transferred to a microcentrifuge tube, and precipitated with ice-cold 5% TCA.
Animal Admin Male db/db (Leprdb/db) mice, together with nondiabetic control db/m mice on C57BLKs/J background, are used. INO-1001 and PJ-34 treatment are initiated at 5 weeks of age. In sterile water that is sweetened with NutraSweet, 4.8 g/L 3-Aminobenzamide and 2.4 g/L PJ-34 is dissolved. Control animals receive sweetened water only. The average inhibitor consumption is 60 mg/kg 3-Aminobenzamide and 30 mg/kg PJ-34.
References

[1]. Brock WA, et al. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase. Cancer Lett. 2004 Mar 18;205(2):155-60.

[2]. Radovits T, et al. Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. Eur J Pharmacol. 2007 Jun 14;564(1-3):158-66.

[3]. Szabo C, et al. Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes. 2006 Nov;55(11):3004-12.

[4]. Clark RS, et al. Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice. J Neurotrauma. 2007 Aug;24(8):1399-405.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 329.6±25.0 °C at 760 mmHg
Melting Point 115-116 °C(lit.)
Molecular Formula C7H8N2O
Molecular Weight 136.151
Flash Point 153.2±23.2 °C
Exact Mass 136.063660
PSA 69.11000
LogP 0.33
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.633
Water Solubility ethanol: 50 mg/mL, clear, faintly yellow

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CU8992000
CHEMICAL NAME :
Benzamide, m-amino-
CAS REGISTRY NUMBER :
3544-24-9
BEILSTEIN REFERENCE NO. :
2802373
LAST UPDATED :
199612
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C7-H8-N2-O
MOLECULAR WEIGHT :
136.17
WISWESSER LINE NOTATION :
ZVR CZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Mammal - species unspecified Fibroblast
DOSE/DURATION :
1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 254,13,1991

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P280-P301 + P312 + P330-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CU8992000
HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

meta-aminobenzoylamine
m-Aminobenzamide
3-Aminobenzimide
Benzamide,m-amino
Benzamide, 3-amino-
3-Aminobenzamide
3-Amino-benzamide
MFCD00007989
EINECS 222-586-9
Benzamide,3-amino
INO1001
meta-aminobenzamide
3-NH2-Ph-CO-NH2
5-amino-benzamide
INO-1001
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: INO-1001
  • Price: $100.0/100mg $200.0/250mg $400.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

Get all suppliers and price by the below link:

3-Aminobenzamide suppliers

Price: $66/10mM*1mLinDMSO

Reference only. check more 3-Aminobenzamide price

Related Compounds: More...
3-Aminobenzamide oxime
100524-07-0
4-chloro-3-aminobenzamide
19694-10-1
N-methyl-3-aminobenzamide
25900-61-2
N-n-butyl 3-aminobenzamide
6837-99-6
N'-propyl-3-aminobenzamide
81882-78-2
N,N-dimethyl-3-aminobenzamide
33322-60-0
N-phenylmethyl-3-aminobenzamide
54977-91-2
N-(Adamantan-1-yl)-3-aminobenzamide
57277-47-1
N-(3-isopropylphenyl)-4-methyl-3-aminobenzamide
870221-09-3
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