Biochimica et Biophysica Acta (BBA) - General Subjects 2012-09-01

Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes

Barbara Viljetić, Irena Labak, Senka Majić, Anamaria Štambuk, Marija Heffer, Barbara Viljetić, Irena Labak, Senka Majić, Anamaria Štambuk, Marija Heffer

Index: Biochim. Biophys. Acta 1820(9) , 1437-43, (2012)

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Abstract

Background Mono-, di- and trisialo gangliosides are major glycosphingolipids in the brain of higher vertebrates involved in lipid raft assembly. In contrast, the fish brain is abundant in polisialo-gangliosides, whose function is implicated in the modulation of repulsive and attractive intercellular interactions during embryonic development and a temperature adaptation process. The histological distribution of gangliosides is usually studied in rodent and mammalian brains, but to date it has not been described in the case of fish brain.