Applied and Environmental Microbiology 2000-03-01

Reductive cleavage of demeton-S-methyl by Corynebacterium glutamicum in cometabolism on more readily metabolizable substrates.

L Girbal, D Hilaire, S Leduc, L Delery, J L Rols, N D Lindley

Index: Appl. Environ. Microbiol. 66(3) , 1202-4, (2000)

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Abstract

Corynebacterium glutamicum is able to biotransform demeton-S-methyl, an organophosphorus compound, during cometabolism with more readily metabolizable substrates. Among the cosubstrates used, fructose is the growth substrate that is most favorable for demeton-S-methyl biotransformation. The reaction mechanism of demeton-S-methyl biotransformation involves reductive cleavage of an S-C bond, which leads to accumulation of dimethyl thiophosphate in the culture medium.