Bioorganic & Medicinal Chemistry Letters 2007-09-01

Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.

Michael A Letavic, Emily M Stocking, Ann J Barbier, Pascal Bonaventure, Jamin D Boggs, Brian Lord, Kirsten L Miller, Sandy J Wilson, Nicholas I Carruthers

Index: Bioorg. Med. Chem. Lett. 17(17) , 4799-803, (2007)

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Abstract

The design, synthesis, and in vitro activity of a series of novel 5-ethynyl-2-aryloxybenzylamine-based histamine H(3) ligands that are also serotonin reuptake transporters is described.