Chirality 2012-12-01

Noncovalent immobilization of ionic-tagged box-Cu(OAc)2 complex and its application in asymmetric Henry reaction.

Zhi-Huai Li, Zhi-Ming Zhou, Xiao-Yan Hao, Jun Zhang, Xiao Dong, Ying-Qiang Liu

Index: Chirality 24(12) , 1092-5, (2012)

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Abstract

Immobilized Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding by SBA-15 was applied to asymmetric Henry reaction, and good enantioselectivities were obtained (up to 83% ee) between 2-methoxybenzaldehyde and CH(3)NO(2) in isopropyl alcohol (iPrOH). The catalyst could be reused seven times without any obvious loss in enantioselectivity. For the first time, this facile and clean immobilization method is applied to the use of bis(oxazolines) complexes.Copyright © 2012 Wiley Periodicals, Inc.