Clinical and Experimental Dermatology 2012-06-01

Mesna-induced photodistributed dermatosis.

C Y Lin, M Keefe

Index: Clin. Exp. Dermatol. 37(4) , 358-60, (2012)

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Abstract

We present the case of a 41-year-old man who developed a photodistributed eruption 1 month after being started on 2-mercaptoethane sulfonate sodium (mesna) for treatment of cyclophosphamide-induced haemorrhagic cystitis. The patient had a background history of Wegener granulomatosis, and had been taking cyclophosphamide at a stable dose of 150 mg daily for the previous 3 years. Complete resolution of the rash occurred within 8 weeks of cessation of mesna. This is the first reported case, to our knowledge, of mesna-induced photodistributed dermatosis. Early recognition of this condition will ensure prompt cessation of the culprit medication, and consideration of alternative management of haemorrhagic cystitis.© The Author(s). CED © 2011 British Association of Dermatologists.