Toxicon 1988-01-01

Staphylococcal alpha toxin--recent advances.

M Thelestam, L Blomqvist

Index: Toxicon 26 , 55-65, (1988)

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Abstract

The elucidation of the amino acid sequence of alpha toxin in 1984 has greatly promoted our understanding of the basic biochemistry and interaction of this toxin with membranes. These aspects are discussed and the concept of alpha toxin as a channel forming protein is critically evaluated. The lethal action of alpha toxin has not yet been clarified, but the previously postulated action as a neurotoxin is not supported by recent observations.