MICROWAVE ASSISTED SYNTHESIS OF BIOLOGICALLY ACTIVE 4-HYDROXY-7V-(PHENYLCARBONYL)-2H-1, 2-BENZOTHIAZINE-3-CARBOHYDRAZIDE …

M Zaheer, M Zia-Ur-Rehman, S Rahman…

Index: Zaheer, Muhammad; Zia-Ur-Rehman, Muhammad; Rahman, Salma; Ahmed, Naveed; Chaudhary, Muhammad Nawaz Journal of the Chilean Chemical Society, 2012 , vol. 57, # 4 p. 1492 - 1496

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Abstract

ABSTRACT Microwave assisted synthesis of a series of 4-hydroxy-N'-(phenylcarbonyl)-2H- 1, 2-benzothiazine-3-carbohydrazide 1, 1-dioxides from sodium saccharin is reported. Sodium o-benzosulfimide was N-alkylated with ethyl chloroacetate followed by base catalyzed ring expansion to six membered 1, 2-benzothiazine through Gabriel-Coleman type rearrangement yielding ethyl 4-hydroxy-2H-1, 2-benzothiazine-3-carboxylate 1, 1- ...