Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1995-01-01

Genotoxicity testing of five compounds in three Drosophila short-term somatic assays.

M Batiste-Alentorn, N Xamena, A Creus, R Marcos

Index: Mutat. Res. 341(3) , 161-7, (1995)

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Abstract

To provide further background data for the somatic mutation and/or recombination tests in Drosophila melanogaster, we have evaluated the response in 3 assays (zeste-white, white-ivory and wing spot) of 5 chemicals classified by the U.S. National Toxicology Program (NTP) as genotoxic non-carcinogens (or ambiguous). The selected compounds were 2-chloromethylpyridine, 1-nitronaphthalene, 4-nitro-o-phenylenediamine, 3-nitropropionic acid and p-phenylenediamine. Our results show that all the compounds tested produce significant increases in the frequency of mutant clones, in at least one of the assays, p-phenylenediamine being the compound which presents a clearer mutagenic activity, and the wing spot test, the assay that detects more genotoxic compounds (4/5).