1,2-Diamino-4-nitrobenzene
1,2-Diamino-4-nitrobenzene structure
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Common Name | 1,2-Diamino-4-nitrobenzene | ||
|---|---|---|---|---|
| CAS Number | 99-56-9 | Molecular Weight | 153.139 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 421.1±25.0 °C at 760 mmHg | |
| Molecular Formula | C6H7N3O2 | Melting Point | 199-201 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 208.5±23.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Safety and mutagenicity evaluation of Vigiis 101 powder made from Lactobacillus paracasei subsp. paracasei NTU 101.
Regul Toxicol Pharmacol 71(2) , 148-57, (2015) The aim of the present work was to assess the genotoxic activity and the potential for toxicity upon repeated dosing of "Vigiis 101" powder, a probiotic consisting of dried bacteria Lactobacillus paracasei subsp. paracasei NTU 101. Results of the Ames test in... |
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Pre-clinical in vitro and in vivo safety evaluation of bovine whey derived osteopontin, Lacprodan® OPN-10.
Food Chem. Toxicol. 73 , 59-70, (2014) Lacprodan® OPN-10 is a proprietary whey-based protein product that contains bovine-derived osteopontin (OPN), found in human milk and other bodily tissues. In vitro genotoxicity tests conducted according to accepted guidelines at up to 5000μg/plate OPN failed... |
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Metabolic activation of three arylamines and two organophosphorus insecticides by coriander (Coriandrum sativum) a common edible vegetable.
Toxicol. Lett. 125(1-3) , 39-49, (2001) Organophosphorus insecticides and arylamines, widely distributed in the environment, can be activated into mutagens by plants. Plant activation of three aromatic amines, 4-nitro-o-phenylenediamine (NOP), m-phenylenediamine (m-PDA) and 2-aminofluorene (2AF), a... |
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Antimutagenicity of coriander (Coriandrum sativum) juice on the mutagenesis produced by plant metabolites of aromatic amines.
Toxicol. Lett. 153(2) , 283-92, (2004) Aromatic amines are metabolically activated into mutagenic compounds by both animal and plant systems. The 4-nitro-o-phenylenediamine (NOP) is a well-known direct-acting mutagen whose mutagenic potential can be enhanced by plant metabolism; m-phenylenediamine... |
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Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts.
Evid. Based. Complement. Alternat. Med. 2011 , 323276, (2011) Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by... |
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Base-pair mutation caused by four nitro-group containing aromatic amines in Salmonella typhimurium TA100, TA104, TA4001 and TA4006.
Mutat. Res. 395(2-3) , 223-7, (1997) Among p-phenylenediamine, benzidine and the analogues we previously tested, only the nitro-group containing 2-nitro-p-phenylenediamine, 3-nitro-o-phenylenediamine, 4-nitro-o-phenylenediamine and 4,4'-dinitro-2-biphenylamine caused base-pair reversion in the h... |
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Comparison of the mutagenic specificity induced by four nitro-group-containing aromatic amines in Salmonella typhimurium his genes.
Mutat. Res. 465(1-2) , 165-71, (2000) Four nitrated aromatic amines (2-nitro-p-phenylenediamine [2NPD], 3-nitro-o-phenylenediamine [3NPD], 4-nitro-o-phenylenediamine [4NPD] and 4,4'-dinitro-2-biphenylamine [DNBA]) are direct-acting mutagens in Salmonella typhimurium strain TA100. These compounds ... |
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Genotoxicity testing of five compounds in three Drosophila short-term somatic assays.
Mutat. Res. 341(3) , 161-7, (1995) To provide further background data for the somatic mutation and/or recombination tests in Drosophila melanogaster, we have evaluated the response in 3 assays (zeste-white, white-ivory and wing spot) of 5 chemicals classified by the U.S. National Toxicology Pr... |
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In vitro enhancement of the mutagenicity of 4-nitro-o-phenylenediamine by plant S-9.
Environ. Mutagen. 7(1) , 73-85, (1985) The direct-acting mutagen 4-nitro-o-phenylenediamine (NOP) was activated in vitro by pea or tobacco S-9 into a more potent mutagen in Salmonella typhimurium strain TA98. NOP mutagenicity was not altered by Aroclor 1254-induced rat liver S-9. The plant S-9 act... |
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The metabolic activation of 4-nitro-o-phenylenediamine by chlorophyll-containing plant extracts: the relationship between mutagenicity and antimutagenicity.
Mutat. Res. 250(1-2) , 79-86, (1991) Chlorophyllin, the sodium and copper salt of chlorophyll, chlorophyll a, and chlorophyll b were tested for their ability to inhibit the mutagenic activity of the direct-acting mutagen 4-nitro-o-phenylenediamine (NOP) and its plant-activated mutagenic enhancem... |