The mechanism of the reaction of nicotinic acid 1-oxide with acetic anhydride.

H NAGANO, Y NAWATA, M HAMANA

Index: Nagano, Hiroyuki; Nawata, Yoshiharu; Hamana, Masatomo Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 10 p. 4068 - 4077

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Citation Number: 14

Abstract

In order to elucidate the mechanism of the 2-acetylation in the reaction of nicotinic acid 1- oxide (2a) with boiling acetic anhydride, thermal reactions and reactions with hot acetic anhydride have been explored with 3-X-pyridine 1-oxides (2). The former reactions of 2d (X= CONHAc), 2f (X= CONMeAc), 2h (X= CH 2 OAc) and 2j [X= CH (OAc) 2] result in recovery or decomposition. The latter reactions of 2c (X= CONH 2), 2d, 2e (X= CONHMe), 2h and 2j ...