Methyl nicotinate

Modify Date: 2024-01-02 11:13:58

Methyl nicotinate Structure
Methyl nicotinate structure
 Common Name Methyl nicotinate
CAS Number 93-60-7 Molecular Weight 137.136
Density 1.1±0.1 g/cm3 Boiling Point 209.0±0.0 °C at 760 mmHg
Molecular Formula C7H7NO2 Melting Point 42-44 °C(lit.)
MSDS Chinese USA Flash Point 95.6±0.0 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Methyl nicotinate


Methyl nicotinate, the methyl ester of Niacin found in alcoholic beverages, that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain[1].

 Names

Name Methyl nicotinate
Synonym More Synonyms

 Methyl nicotinate Biological Activity

Description Methyl nicotinate, the methyl ester of Niacin found in alcoholic beverages, that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain[1].
Related Catalog
References

[1]. L. Johnston, et al. Muscle and joint pain: topical anti-inflammatories and analgesics: therapeutic. Professional Nursing Today, Volume 17, Issue 1, Jan 2013, p. 4-5.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 209.0±0.0 °C at 760 mmHg
Melting Point 42-44 °C(lit.)
Molecular Formula C7H7NO2
Molecular Weight 137.136
Flash Point 95.6±0.0 °C
Exact Mass 137.047684
PSA 39.19000
LogP 0.88
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.511
Water Solubility NEGLIGIBLE

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QT1925000
CHEMICAL NAME :
Nicotinic acid, methyl ester
CAS REGISTRY NUMBER :
93-60-7
BEILSTEIN REFERENCE NO. :
0113951
LAST UPDATED :
199712
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C7-H7-N-O2
MOLECULAR WEIGHT :
137.15
WISWESSER LINE NOTATION :
T6NJ CVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,428,1948
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,691,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80460 No. of Facilities: 100 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 2857 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/38
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS QT1925000
HS Code 2936290090

 Synthetic Route

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

EINECS 202-261-8
NIACIN METHYL ESTER
Methyl nictinate
Methylpyridin-3-carboxylat
3-methoxycarbonylpyridine
nicotinic acid methyl ester
methylnicotinicacid
3-pyridinecarboxylic acid methyl ester
MFCD00006388
3-Pyridinecarboxylic acid, methyl ester
methyl 3-nicotinate
Methyl nicotinate
Nikomet
FEMA 3709
pyridine-3-carboxylic acid methyl ester
Nicometh
methyl 3-pyridinecarboxylate
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