European Journal of Medicinal Chemistry 2012-09-01

Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents.

Ola H Rizk, Omaima G Shaaban, Ibrahim M El-Ashmawy

Index: Eur. J. Med. Chem. 55 , 85-93, (2012)

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Abstract

Some new substituted thienopyrimidine derivatives comprising thioxo, thioalkyl and pyrazolyl derivatives as well as fused thienotriazolopyrimidine and thienopyrimidinotriazine ring systems were prepared from 3-benzyl-2-hydrazino-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide 4. The designed compounds were evaluated for their anti-inflammatory activity. Compounds 4, 9, 10 and 13 showed the highest anti-inflammatory effect compared with the reference drug diclofenac sodium.Copyright © 2012 Elsevier Masson SAS. All rights reserved.