Synthesis and Biological Evaluation of 2??Substituted??5??(4??nitrophenylsulfonamido) benzoxazoles as Human GST P1??1 Inhibitors, and Description of the Binding Site …

T Ertan??Bolelli, Y Musdal, K Bolelli, S Yilmaz…

Index: Ertan-Bolelli, Tugba; Musdal, Yaman; Bolelli, Kayhan; Yilmaz, Serap; Aksoy, Yasemin; Yildiz, Ilkay; Aki-Yalcin, Esin; Yalcin, Ismail ChemMedChem, 2014 , vol. 9, # 5 p. 984 - 992

Full Text: HTML

Citation Number: 11

Abstract

Abstract Glutathione-S-transferases (GSTs) are enzymes involved in cellular detoxification by catalyzing the nucleophilic attack of glutathione (GSH) on the electrophilic center of numerous of toxic compounds and xenobiotics, including chemotherapeutic drugs. Human GST P1-1, which is known as the most prevalent isoform of the mammalian cytosolic GSTs, is overexpressed in many cancers and contributes to multidrug resistance by directly ...

54995-50-5

2-P-TOLYL-BENZO...

Discovery of 2-arylbenzoxazoles as upregulators of utrophin ...

[Chancellor, Daniel R.; Davies, Kay E.; De Moor, Olivier; Dorgan, Colin R.; Johnson, Peter D.; Lambert, Adam G.; Lawrence, Daniel; Lecci, Cristina; Maillol, Carole; Middleton, Penny J.; Nugent, Gary; Poignant, Severine D.; Potter, Allyson C.; Price, Paul D.; Pye, Richard J.; Storer, Richard; Tinsley, Jonathon M.; Van Well, Renate; Vickers, Richard; Vile, Julia; Wilkes, Fraser J.; Wilson, Francis X.; Wren, Stephen P.; Wynne, Graham M. Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3241 - 3250]