2,4-Diaminophenol dihydrochloride

Modify Date: 2024-01-02 07:38:16

2,4-Diaminophenol dihydrochloride structure	Common Name	2,4-Diaminophenol dihydrochloride
	CAS Number	137-09-7	Molecular Weight	197.062
	Density	1.343 g/cm3	Boiling Point	347.4ºC at 760 mmHg
	Molecular Formula	C₆H₁₀Cl₂N₂O	Melting Point	222 °C (dec.)(lit.)
	MSDS	USA	Flash Point	163.9ºC
	Symbol	GHS06	Signal Word	Danger

Name	2,4-Diaminophenol dihydrochloride
Synonym	More Synonyms

Density	1.343 g/cm3
Boiling Point	347.4ºC at 760 mmHg
Melting Point	222 °C (dec.)(lit.)
Molecular Formula	C₆H₁₀Cl₂N₂O
Molecular Weight	197.062
Flash Point	163.9ºC
Exact Mass	196.017014
PSA	72.27000
LogP	3.32300
Vapour Pressure	2.68E-05mmHg at 25°C
Stability	Stable. Incompatible with strong oxidizing agents, acids. Heat and light sensitive.
Water Solubility	27.5 g/100 mL (15 ºC)

2,4-Diaminophenol dihydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SK7600000

CHEMICAL NAME :: Phenol, 2,4-diamino-, dihydrochloride

CAS REGISTRY NUMBER :: 137-09-7

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C6-H8-N2-O.2Cl-H

MOLECULAR WEIGHT :: 197.08

WISWESSER LINE NOTATION :: ZR CZ DQ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6500 mg/kg/13W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg/4D-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg/16D-I

TOXIC EFFECTS :: Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 325 mg/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 2 mg/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,143,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2516 No. of Facilities: 809 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 6638 (estimated) No. of Female Employees: 4211 (estimated)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335
Precautionary Statements	P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	SK7600000
Packaging Group	III
Hazard Class	6.1
HS Code	29222900

2,4-Dinitrophenol

CAS#:51-28-5

~90%

2,4-Diaminophen...

CAS#:137-09-7

Literature: Mischenko; Alexandr P.; Gryaznov; Vladimir M.; Gakh; Igor G.; Parbuzina; Iraida L.; Savitsky; Evgeny M.; Polyakova; Viktoria P.; Roshan; Natalia R. Patent: US4323708 A1, 1982 ;

Precursor 1
CAS#:51-28-5 2,4-Dinitrophenol
DownStream 10
CAS#:293737-80-1 2-(2-BROMOPHENY... CAS#:102-33-0 N-(3-amino-4-hy... CAS#:13676-48-7 2-(3-aminopheny... CAS#:13676-47-6 5-Amino-2-(4-am...
CAS#:120-83-2 2,4-Dichlorophenol CAS#:116248-09-0 2-(4-ETHYL-PHEN... CAS#:116248-11-4 2-(4-DIMETHYLAM... CAS#:116248-10-3 2-(4-fluorophen...
CAS#:851402-83-0 4-bromo-6-(5-br... CAS#:90915-19-8 N-(2-methylbenz...

HS Code	2923900090
Summary	2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I: Results for nine compounds.

Environ. Mutagen. 9(2) , 143-60, (1987)

Nine substances were tested for their mutagenic potential in the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay, by means of procedures based upon those described by Clive and Spector (Muta...

NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,4-Diaminophenol Dihydrochloride (CAS NO. 137-09-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

Natl. Toxicol. Program Tech. Rep. Ser. 401 , 1-232, (1992)

2,4-Diaminophenol dihydrochloride is used in the manufacture of dyes and as a color accelerator in photographic developers. Toxicology and carcinogenesis studies were conducted by administering 2,4-di...

[Preparation of antibody erythrocyte for indicating arbovirus antigens].

Vopr. Virusol. (1) , 98-102, (1982)