Organic Letters 2012-12-21

Three-component reaction of propargyl amines, sulfonyl azides, and alkynes: one-pot synthesis of tetrasubstituted imidazoles.

Zheng Jiang, Ping Lu, Yanguang Wang

Index: Org. Lett. 14(24) , 6266-9, (2012)

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Abstract

An efficient and straightforward strategy for the synthesis of tetrasubstituted imidazoles from propargyl amines, sulfonyl azides, and terminal alkynes is described. N-sulfonyl ketenimine and aminoallene are believed to be the key intermediates for this two-step one-pot transformation.