Studies on 4 (1H)-quinazolinones. 5. Synthesis and antiinflammatory activity of 4 (1H)-quinazolinone derivatives

K Ozaki, Y Yamada, T Oine, T Ishizuka…

Index: Ozaki; Yamada; Oine; Ishizuka; Iwasawa Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 568 - 576

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Citation Number: 122

Abstract

(VII, Table 11, 47) was obtained by the reduction of 2-isopropyl-l-phenyl-4 (1H)- quinazolinone (3, Table I) with sodium borohydride. The reaction of 2-anilinobenzonitrile with isopropylmagnesium bromide, followed by careful quenching with water, gave the ketimine VIII, which was converted to 4-isopropyl-l-phenyl-2 (1H)-quinazolinone (IX, Table 11, 44) by cyclization using phosgene. N-Isopropylanthranilic acids X were prepared by ...